ACS Publications
Herein, we describe the development of the high-throughput experimentation platform and function in AbbVie’s Discovery Chemistry organization. The strategy and approach tailored specifically to medicinal chemistry needs are discussed. Additionally, we disclose the top reaction conditions for the most requested transformations obtained by analysis of the combined data set generated by the platform over five years.
For details:
Design and Implementation of a High-Throughput Experimentation Platform to Accelerate Drug Discovery
Amanda W. Dombrowski, Ana L. Aguirre, and Ying Wang
AbbVie, Inc., North Chicago, Illinois 60064, United States
ACS Publications
https://doi.org/10.1021/acs.jmedchem.5c00814
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